Research Activity
The research program of the Hegedus group
centers on the development of transition metal organometallic
compounds as reagents in organic synthesis. The discovery in
these laboratories some years ago that photolysis of chromium
carbene complexes generates species with ketene-like reactivity
has opened pathways to a number of classes of biologically active
compounds
Current research efforts involves the synthesis
of antiviral nucleoside analogs via chromium-carbene-derived optically
active cyclobutanones;
anti HIV cyclams via chromium carbene derived
azapenams
and pseudo peptides via chromium carbene
derived peptides.
In addition, new methodology problems are
constantly evolving. As they develop, applications to the synthesis
of biologically active compounds are planned.
Students recently employed
Mike Miller - Schering Plough
John Montgomery - Assistant Professor, Wayne
State University
Shon Pulley - Assistant Professor, University
of Missouri
John Masters - Eli Lilly
Other Information:
Postdoctoral Fellowships
John Masters - American Cancer Society
Shon Pulley - National Institutes of Health
Mike Miller - National Institutes of Health
